| タイトル | Structural Insights into the Broad Substrate Recognition Mechanism of Human ABCD3 |
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| ジャーナル・号・ページ | To Be Published |
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| 掲載日 | 2025年8月3日 (構造データの登録日) |
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著者 | Aiba S / Okamoto HH / Tomita A / Sano F / Kusakizako T / Nureki O |
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リンク | PubMedで検索 |
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| 手法 | EM (単粒子) |
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| 解像度 | 2.94 - 3.81 Å |
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| 構造データ | EMDB-65674, PDB-9w62: Cryo-EM structure of human ABCD3 in inward-facing conformation in the presence of phytanoyl-CoA 手法: EM (単粒子) / 解像度: 3.28 Å EMDB-65675, PDB-9w63: Cryo-EM structure of C20:5-CoA bound state human ABCD3 in inward-facing conformation 手法: EM (単粒子) / 解像度: 3.29 Å EMDB-65676, PDB-9w64: Cryo-EM structure of CHS bound state human ABCD3 in inward-facing conformation 手法: EM (単粒子) / 解像度: 3.81 Å EMDB-65677, PDB-9w65: Cryo-EM structure of ATP bound state human ABCD3 in inward-facing conformation 手法: EM (単粒子) / 解像度: 2.94 Å EMDB-65678, PDB-9w66: Cryo-EM structure of ATP bound state human ABCD3 in outward-facing conformation 手法: EM (単粒子) / 解像度: 3.3 Å |
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| 化合物 | ChemComp-LBN: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine / リン脂質*YM
ChemComp-3IX: S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate
ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP, エネルギー貯蔵分子*YM
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| 由来 | homo sapiens (ヒト)
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キーワード | TRANSPORT PROTEIN / ABC transporter |
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