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TitleSelective GLUT9 inhibitors for hyperuricemia via intestinal mechanism
Journal, issue, pagesActa Pharm Sin B, Year 2026
Publish dateJul 3, 2025 (structure data deposition date)
AuthorsZhao Z / Sun Z / Shen Z / Zheng F / Zhang X / Luo Z / He Y / Xu Y / Wu Z / Ke J ...Zhao Z / Sun Z / Shen Z / Zheng F / Zhang X / Luo Z / He Y / Xu Y / Wu Z / Ke J / Li J / Wu T / Zhang Q / Tian Y / Pan X / Pang J / Chen J
External linksActa Pharm Sin B / Search PubMed
MethodsEM (single particle)
Resolution3.14 Å
Structure data

65253

9vpg

EMDB-65253, PDB-9vpg:
Cryo-EM structure of human urate transporter GLUT9 bound to a selective inhibitor SG4
Method: EM (single particle) / Resolution: 3.14 Å

Chemicals

PDB-1etz:
THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / complex / selective inhibitor

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