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TitleCryo-EM structure of cemsidomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly
Journal, issue, pagesTo Be Published
Publish dateMay 17, 2025 (structure data deposition date)
AuthorsDeng ZH / Ai HS / Liu L
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.71 Å
Structure data

64663

9v0f

EMDB-64663, PDB-9v0f:
Cryo-EM structure of cemsidomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly
Method: EM (single particle) / Resolution: 3.71 Å

Chemicals


PDB Unreleased entry

PDB-1eqo: Unknown entry

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / Molecular glue degrader / cemsidomide / CRL4 ubiquitin ligase / DDB1 / CRBN / Complex

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