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TitleCryo-EM structure of the human P2X2/3 heteromer receptor bound to AF-219
Journal, issue, pagesTo Be Published
Publish dateMay 13, 2025 (structure data deposition date)
AuthorsZhang J / Cheng XY
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.64 Å
Structure data

64571

9ux3

EMDB-64571, PDB-9ux3:
Cryo-EM structure of the human P2X2/3 heteromer receptor bound to AF-219
Method: EM (single particle) / Resolution: 2.64 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-AF9:
5-[2,4-bis(azanyl)pyrimidin-5-yl]oxy-2-methoxy-4-propan-2-yl-benzenesulfonamide

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / P2X ion channal

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