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TitleCryo-EM structure of mezigdomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly
Journal, issue, pagesTo Be Published
Publish dateMay 7, 2025 (structure data deposition date)
AuthorsDeng ZH / Ai HS / Liu L
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.41 Å
Structure data

64512

9uum

EMDB-64512, PDB-9uum:
Cryo-EM structure of mezigdomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly
Method: EM (single particle) / Resolution: 3.41 Å

64515

9uuq

EMDB-64515, PDB-9uuq:
Cryo-EM structure of thalidomide-organized CRL4-DDB1-CRBN-IKZF3(ZF2-ZF3)-UbcH5a-Ub ubiquitylation assembly
Method: EM (single particle) / Resolution: 3.41 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-QFC:
Mezigdomide

ChemComp-EF2:
S-Thalidomide

Source
  • homo sapiens (human)
KeywordsLIGASE / Molecular glue degrader / mezigdomide / CRL4 ubiquitin ligase / DDB1 / CRBN / Complex / thalidomide

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