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TitleSARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition
Journal, issue, pagesTo Be Published
Publish dateApr 12, 2025 (structure data deposition date)
AuthorsZhang W / Zhou Q / Zhang J / Zheng S / Wang X
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.85 Å
Structure data

64139

9ugj

EMDB-64139, PDB-9ugj:
Structure of SARM1 bound to SIR3-ADPR
Method: EM (single particle) / Resolution: 3.85 Å

Chemicals

PDB-1eo4:
ECORV BOUND TO MN2+ AND COGNATE DNA CONTAINING A 3'S SUBSTITION AT THE CLEAVAGE SITE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / NAD(+) hydrolase / cell death / apoptosis

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