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Structure paper

TitleSingle-Dose Therapeutic Antibody Protects against SFTSV in Mice and Rhesus Macaques
Journal, issue, pagesVita, Year 2026
Publish dateJan 23, 2025 (structure data deposition date)
AuthorsBi JH / Dai Z / Hong X / Zhang Y / Lu S / Wang Q / Liu Y / Li X / Li M / Song G ...Bi JH / Dai Z / Hong X / Zhang Y / Lu S / Wang Q / Liu Y / Li X / Li M / Song G / Chen Q / Yu W / Yang Y / Ma Y / Liu H / Meng X / Wang Z / Liu D / Sun R / Sun Q / Li S / Zhou Q / Li D
External linksVita / Search PubMed
MethodsEM (single particle)
Resolution2.99 - 3.5 Å
Structure data

63246

9loe

EMDB-63246, PDB-9loe:
Cryo-EM structure of SFTSV Gn in complex with ZS004-1C5
Method: EM (single particle) / Resolution: 2.99 Å

63247

9lof

EMDB-63247, PDB-9lof:
Cryo-EM structure of SFTSV Gn in complex with ZS01S-336
Method: EM (single particle) / Resolution: 3.03 Å

63248

9log

EMDB-63248, PDB-9log:
Cryo-EM structure of SFTSV Gn in complex with ZS01S-65
Method: EM (single particle) / Resolution: 3.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe fever with thrombocytopenia syndrome virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Viral glycoprotein / neutralizing antibody / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex

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