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TitleDe novo discovery of unnatural and potent conotoxin-like bicyclic peptides through a phage-encoded library
Journal, issue, pagesTo Be Published
Publish dateJan 20, 2025 (structure data deposition date)
AuthorsCao X / Chen H / Wang X / Yang X / Wang T / Zhou L / Shi C / Liu S / Liu L / Tian C / Sun D
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.94 Å
Structure data

63228

9ln7

EMDB-63228, PDB-9ln7:
Alpha-7 nicotinic acetylcholine receptor bound to inhibitory bicyclic peptide KP2007 in a resting state.
Method: EM (single particle) / Resolution: 2.94 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / nicotinic acetylcholine receptor

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