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TitleStructure and function of a pair of non-competing monoclonal antibodies against Langya henipavirus attachment glycoprotein.
Journal, issue, pagesCell Rep, Vol. 44, Issue 10, Page 116407, Year 2025
Publish dateOct 28, 2025
AuthorsWenting Li / Songyue Wu / Qi Gui / Congcong Liu / Bing Zhou / Hu Yan / Yuehong Sun / Qing Fan / Yuzheng Zhou / Huimin Guo / Shilong Tang / Xiangyang Ge / Bin Ju / Renhong Yan / Zheng Zhang /
PubMed AbstractLangya henipavirus (LayV) is a zoonotic Parahenipavirus (Para-HNV) identified in recent years, discovered via surveillance of febrile patients with recent animal exposure in eastern China. The ...Langya henipavirus (LayV) is a zoonotic Parahenipavirus (Para-HNV) identified in recent years, discovered via surveillance of febrile patients with recent animal exposure in eastern China. The attachment glycoprotein (G) of HNV is critical for host cell entry and a key immune target. However, LayV-G exhibits notable antigenic differences from G of highly pathogenic bat-borne Hendra virus (HEV) and Nipah virus (NiV), implying vaccines or antibody therapies developed against HeV/NiV-G might be ineffective against LayV. Here, we immunize mice with LayV-G ectodomain and isolate a panel of LayV-G-targeting monoclonal antibodies (mAbs). We characterize two potent mAbs with pronounced crystallizable fragment (Fc)-mediated antiviral function and determine their cryo-electron microscopy (cryo-EM) structure binding to distinct epitopes of LayV-G head domain at a resolution of 2.92 Å, revealing antibody recognition mechanisms and potential conformational dynamics of LayV-G. Overall, our study defines two function-related epitopes of LayV-G, laying the foundation for therapeutic antibody development and vaccine design.
External linksCell Rep / PubMed:41071677
MethodsEM (single particle)
Resolution2.92 Å
Structure data

63031

9leo

EMDB-63031, PDB-9leo:
LayV-G Head in complex of LayG-1069 and LayG-1133
Method: EM (single particle) / Resolution: 2.92 Å

Source
  • langya virus
  • mus musculus (house mouse)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / complex / virus protein / Antibody / Glycoprotein / Henipa Virus / VIRAL PROTEIN-IMMUNE SYSTEM complex

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