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TitleStructurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection.
Journal, issue, pagesCell, Vol. 188, Issue 22, Page 6253-6265.e14, Year 2025
Publish dateOct 30, 2025
AuthorsBin Ju / Congcong Liu / Jingjing Zhang / Yaning Li / Haonan Yang / Bing Zhou / Baoying Huang / Jianrong Ma / Jiahan Lu / Lin Cheng / Zhe Cong / Lin Zhu / Tianhao Shi / Yuehong Sun / Na Li / Ting Chen / Miao Wang / Shilong Tang / Xiangyang Ge / Juanjuan Zhao / Wen-Jie Tan / Renhong Yan / Jing Xue / Zheng Zhang /
PubMed AbstractThe A35 protein, expressed on the enveloped virion of monkeypox (mpox) virus (MPXV), is essential for viral infection and spread within the host, making it an effective antiviral target. In this ...The A35 protein, expressed on the enveloped virion of monkeypox (mpox) virus (MPXV), is essential for viral infection and spread within the host, making it an effective antiviral target. In this study, we demonstrated two human anti-A35 monoclonal antibodies (mAbs) displayed potential protection against MPXV in CAST/EiJ mice and rhesus macaques. Using cryo-electron microscopy, we determined two high-resolution structures of the A35 dimer in complex with the fragment of antigen binding of mAb 975 or mAb 981, revealing detailed interactions at the antigen-antibody interfaces. Structural analysis showed that these structurally conserved mAbs bind to a groove region at the interface of A35 dimer. Overall, we provided a proof of concept for a single administration of anti-A35 mAbs mitigating the pathogenic effects of MPXV infection in rhesus macaques. These human-derived mAbs could be served as antibody drug candidates, and their binding models to the A35 dimer will provide valuable insights for future vaccine design.
External linksCell / PubMed:40865530
MethodsEM (single particle)
Resolution3.2 Å
Structure data

62650

9kyz

EMDB-62650, PDB-9kyz:
A35 of MPXV in complex with mAb975
Method: EM (single particle) / Resolution: 3.2 Å

Source
  • homo sapiens (human)
  • monkeypox virus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / envelope glycoprotein / VIRAL PROTEIN-IMMUNE SYSTEM complex

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