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TitleMonoclonal antibodies against human TMPRSS2 prevent infection by any SARS-CoV-2 variant.
Journal, issue, pagesiScience, Vol. 28, Issue 9, Page 113424, Year 2025
Publish dateSep 19, 2025
AuthorsMichishige Harada / Takehisa Matsumoto / Mizuki Yamamoto / Jin Goda / Akiko Idei / Kenichi Ohtaki / Natsuki Kojima / Natsumi Yoneda / Kosuke Miyauchi / Kazushige Katsura / Mariko Ikeda / Kazuharu Hanada / Yoshiko Ishizuka-Katsura / Toshiaki Hosaka / Tamao Hisano / Toshie Kaizuka / Takako Yamamoto / Masashi Matsuda / Manabu Nakayama / Akiko Sugimoto-Ishige / Machie Sakuma / Rina Hashimoto / Kazuo Takayama / Misako Nakayama / Cong Thanh Nguyen / Hirohito Ishigaki / Yasushi Itoh / Yoshinobu Hashizume / Minoru Yoshida / Yasushi Kawaguchi / Makoto Takeda / Haruhiko Koseki / Mikako Shirouzu / Jun-Ichiro Inoue / Takashi Saito /
PubMed AbstractThe transmembrane serine protease 2 (TMPRSS2) plays a critical role in SARS-CoV-2 infection by priming the viral Spike (S) protein for host cell entry and thus represents a potential target for COVID- ...The transmembrane serine protease 2 (TMPRSS2) plays a critical role in SARS-CoV-2 infection by priming the viral Spike (S) protein for host cell entry and thus represents a potential target for COVID-19 therapy. Here monoclonal antibodies (mAbs) against human TMPRSS2 were established for therapeutic application. infection by SARS-CoV-2 of cell lines and human lung organoids was strongly inhibited by the TMPRSS2 mAbs. These mAbs inhibited infection of all SARS-CoV-2 variants tested including omicron. mAbs recognized epitopes different from the enzymatic active site and did not inhibit protease activity, suggesting blockade of steric interactions of S protein-ACE2/TMPRSS2. The inhibitory activity of the mAbs was examined in human /-double knock-in mouse and macaque models. Analysis of viral titers and histopathological analysis of the lung in these infected animals indicated that the TMPRSS2 mAb effectively suppressed viral titers and induction of inflammation .
External linksiScience / PubMed:41393976 / PubMed Central
MethodsEM (single particle)
Resolution3.15 Å
Structure data

62028

9k3t

EMDB-62028, PDB-9k3t:
Cryo-EM structure of TMPRSS2 in complex with Fab fragments of 752 mAb and 2228 mAb
Method: EM (single particle) / Resolution: 3.15 Å

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsMEMBRANE PROTEIN / HYDROLASE / IMMUNE SYSTEM

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