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TitleHuman herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition.
Journal, issue, pagesPLoS Pathog, Vol. 21, Issue 7, Page e1013300, Year 2025
Publish dateJul 9, 2025
AuthorsChu Xie / Xin-Yan Fang / Yuan-Tao Liu / Xian-Shu Tian / Lan-Yi Zhong / Pei-Huang Wu / Hang Zhou / Peng-Lin Li / Yan-Lin Yang / Zi-Ying Jiang / Sen-Fang Sui / Zheng Liu / Mu-Sheng Zeng / Cong Sun /
PubMed AbstractHuman herpesvirus 6B (HHV-6B), a β-herpesvirus that significantly threatens immunocompromised individuals, currently lacks targeted antiviral therapies or vaccines. Glycoprotein B (gB), the primary ...Human herpesvirus 6B (HHV-6B), a β-herpesvirus that significantly threatens immunocompromised individuals, currently lacks targeted antiviral therapies or vaccines. Glycoprotein B (gB), the primary mediator of membrane fusion during viral entry, is a key target for neutralizing antibody (nAb) and vaccine development. In this study, we determined a 2.8 Å cryo-EM structure of the HHV-6B gB ectodomain in its postfusion conformation, unveiling unique N-terminal features and resolving the furin site for the first time in herpesviruses. Comparative analyses highlighted similarities between HHV-6B gB and gB from human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), mapping conserved residues across herpesviruses. Cross-binding assays indicated minimal cross-epitope recognition by nAbs from other herpesviruses, while several potential vulnerable sites on HHV-6B gB were identified. These insights advance our understanding of HHV-6B infection mechanisms and support future development of antibodies or vaccines targeting gB.
External linksPLoS Pathog / PubMed:40632757 / PubMed Central
MethodsEM (single particle)
Resolution2.84 Å
Structure data

61589

9jli

EMDB-61589, PDB-9jli:
Structure of HHV6B glycoprotein B
Method: EM (single particle) / Resolution: 2.84 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • Human gammaherpesvirus 8
  • human herpesvirus 6 strain z29
KeywordsVIRAL PROTEIN / HHV6B / gB

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