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Structure paper

TitleDimerization and substrate recognition of human taurine transporter.
Journal, issue, pagesNat Commun, Vol. 16, Issue 1, Page 6163, Year 2025
Publish dateJul 4, 2025
AuthorsYimin Zhang / Jiahui Chen / Nanhao Chen / Haolin Xiong / Zhengjiang Zhu / Dongxue Yang / Jingpeng Ge / Jie Yu /
PubMed AbstractTaurine is a conditionally essential nutrient and one of the most abundant amino acids in humans, with diverse physiological functions. The cellular uptake of taurine is primarily mediated by the ...Taurine is a conditionally essential nutrient and one of the most abundant amino acids in humans, with diverse physiological functions. The cellular uptake of taurine is primarily mediated by the taurine transporter (TauT), and its dysfunction leads to retinal regeneration, cardiomyopathy, neurological and aging-associated disorders. Here we determine structures of TauT in two states: the apo inward-facing open state and the occluded state bound with substrate taurine or γ-aminobutyric acid (GABA). In addition to monomer, the structures also reveal a TauT dimer, where two cholesterol molecules act as "molecular glue", and close contacts of two TM5 from each protomer mediate the dimer interface. In combination with functional characterizations, our results elucidate the detailed mechanisms of substrate recognition, specificity and transport by TauT, providing a structural framework for understanding TauT function and exploring potential therapeutic strategies for taurine-deficiency-related disorders.
External linksNat Commun / PubMed:40615403 / PubMed Central
MethodsEM (single particle)
Resolution3.05 - 3.98 Å
Structure data

61379

9jd3

EMDB-61379, PDB-9jd3:
membrane proteins
Method: EM (single particle) / Resolution: 3.2 Å

61380

9jd4

EMDB-61380, PDB-9jd4:
taurine transporter
Method: EM (single particle) / Resolution: 3.26 Å

61385

9jd9

EMDB-61385, PDB-9jd9:
taurine transporter
Method: EM (single particle) / Resolution: 3.05 Å

61386

9jda

EMDB-61386, PDB-9jda:
taurine transporter
Method: EM (single particle) / Resolution: 3.23 Å

61392

9jdg

EMDB-61392, PDB-9jdg:
taurine transporter
Method: EM (single particle) / Resolution: 3.23 Å

61393

9jdj

EMDB-61393, PDB-9jdj:
taurine transporter
Method: EM (single particle) / Resolution: 3.5 Å

61395

9jdl

EMDB-61395, PDB-9jdl:
taurine transporter
Method: EM (single particle) / Resolution: 3.98 Å

Chemicals

ChemComp-D12:
DODECANE

ChemComp-LNK:
PENTANE

ChemComp-OCT:
N-OCTANE

ChemComp-D10:
DECANE

ChemComp-HEX:
HEXANE

ChemComp-CLR:
CHOLESTEROL

ChemComp-CL:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID / neurotransmitter, inhibitor*YM

ChemComp-NA:
Unknown entry

ChemComp-TAU:
2-AMINOETHANESULFONIC ACID

ChemComp-C14:
TETRADECANE

ChemComp-DD9:
nonane

ChemComp-HP6:
HEPTANE

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / taurine / transporter

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