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-Structure paper
| タイトル | Structural insights into the closing mechanism of gap junction intercellular channels by carbenoxolone |
|---|---|
| ジャーナル・号・ページ | To Be Published |
| 掲載日 | 2024年7月8日 (構造データの登録日) |
著者 | Lee CW / Jang HS / Woo JS |
リンク | PubMedで検索 |
| 手法 | EM (単粒子) |
| 解像度 | 1.89 - 4.47 Å |
| 構造データ | EMDB-60713, PDB-9inz: ![]() EMDB-60717: Consensus map of Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs, treated with a 5-fold molar excess of carbenoxolone (including D6 and D1 symmetry maps) ![]() EMDB-60741: Consensus map of Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs, treated with a 20-fold molar excess of carbenoxolone (including D6 and D1 symmetry maps) ![]() EMDB-60743: Hemichannel sub-structure of Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs, treated with a 20-fold molar excess of carbenoxolone ![]() EMDB-60753: Consensus map of Cx36/GJD2 gap junction intercellular channel in brain polar lipid nanodiscs (including D6 and D1 symmetry maps) ![]() EMDB-60754: Hemichannel sub-structure of Cx36/GJD2 gap junction intercellular channel (FN conformation) in brain polar lipid nanodiscs ![]() EMDB-60758: Consensus map of Cx36/GJD2 gap junction intercellular channel in brain polar lipid nanodiscs, treated with a 14-fold molar excess of carbenoxolone (including D6 and D1 symmetry maps) EMDB-60759, PDB-9ip5: ![]() EMDB-60761: Consensus map of Cx36/GJD2 gap junction intercellular channel in soybean polar lipid nanodiscs (including D6 and D1 symmetry maps) ![]() EMDB-60762: Hemichannel sub-structure of Cx36/GJD2 gap junction intercellular channel (FN conformation) in soybean polar lipid nanodiscs ![]() EMDB-60763: Consensus map of Cx36/GJD2 gap junction intercellular channel in soybean polar lipid nanodiscs, treated with a 10-fold molar excess of carbenoxolone and incubated shortly (including D6 and D1 symmetry maps) ![]() EMDB-60774: Consensus map of Cx36/GJD2 gap junction intercellular channel in soybean polar lipid nanodiscs, treated with a 10-fold molar excess of carbenoxolone (including D6 and D1 symmetry maps) EMDB-60777, PDB-9ipm: EMDB-60778, PDB-9ipn: EMDB-60779, PDB-9ipo: |
| 化合物 | ![]() ChemComp-C14: ![]() ChemComp-MC3: |
| 由来 |
|
キーワード | MEMBRANE PROTEIN / gap junction / Cx43 / inhibitor / carbenoxolone / Connexin36 |
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