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TitleActivation of a helper NLR by plant and bacterial TIR immune signaling.
Journal, issue, pagesScience, Vol. 386, Issue 6728, Page 1413-1420, Year 2024
Publish dateDec 20, 2024
AuthorsHua Yu / Weiying Xu / Sisi Chen / Xiaoxian Wu / Weiwei Rao / Xiaoxiao Liu / Xiaoyan Xu / Jingqi Chen / Marc T Nishimura / Yu Zhang / Li Wan /
PubMed AbstractPlant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to initiate immune signaling. TIR ...Plant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to initiate immune signaling. TIR domains across different kingdoms have NADase activities and can produce phosphoribosyl adenosine monophosphate/diphosphate (pRib-AMP/ADP) or cyclic ADPR (cADPR) isomers. The lipase-like proteins EDS1 and PAD4 transduce immune signals from sensor TIR-NLRs to a helper NLR called ADR1, which executes immune function. We report the structure and function of an EDS1-PAD4-ADR1 (EPA) heterotrimer in complex with pRib-AMP/ADP activated by plant or bacterial TIR signaling. 2'cADPR can be hydrolyzed into pRib-AMP and thus activate EPA signaling. Bacterial TIR domains producing 2'cADPR also activate EPA function. Our findings suggest that 2'cADPR may be the storage form of the unstable signaling molecule pRib-AMP.
External linksScience / PubMed:39509471
MethodsEM (single particle)
Resolution3.03 - 3.48 Å
Structure data

60520

8zw9

EMDB-60520, PDB-8zw9:
RPS4-TIR induced At EDS1-PAD4-ADR1 heterotrimer
Method: EM (single particle) / Resolution: 3.03 Å

60521

8zwa

EMDB-60521, PDB-8zwa:
HopBY induced At EDS1-PAD4-ADR1 heterotrimer
Method: EM (single particle) / Resolution: 3.48 Å

Chemicals

PDB-1d8a:
E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX

ChemComp-RIA:
2'-O-[(5'-PHOSPHO)RIBOSYL]ADENOSINE-5'-MONOPHOSPHATE

Source
  • arabidopsis thaliana (thale cress)
KeywordsPLANT PROTEIN / Effector-triggered immunity (ETI) / TNL signaling pathway / EDS1 / PAD4 / ADR1

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