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TitleAn antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 10872, Year 2024
Publish dateDec 30, 2024
AuthorsJin-Gen Xu / Shi Chen / Yang He / Xi Zhu / Yanting Wang / Zhifeng Ye / Jin Chuan Zhou / Xuanhui Wu / Lei Zhang / Xiaochen Ren / Huifeng Jia / Haijia Yu / Xiaoyue Wei / Yujie Feng / Xiaofang Chen / Xiaopei Cui / Xianfei Pan / Shaojie Wang / Simin Xia / Hongjie Shang / Yueqing Pu / Wei Xu / Haidong Li / Qian Chen / Zeyu Chen / Manfu Wang / Xiaodong Yan / Hui Shi / Mingwei Li / Yisui Xia / Roberto Bellelli / Shunli Dong / Jun He / Jun Huang / Chen-Leng Cai / Xiangyang Zhu / Yifan Zhan / Li Wan /
PubMed AbstractCD73, an ectoenzyme responsible for adenosine production, is often elevated in immuno-suppressive tumor environments. Inhibition of CD73 activity holds great promise as a therapeutic strategy for ...CD73, an ectoenzyme responsible for adenosine production, is often elevated in immuno-suppressive tumor environments. Inhibition of CD73 activity holds great promise as a therapeutic strategy for CD73-expressing cancers. In this study, we have developed a therapeutic anti-human CD73 antibody cocktail, HB0045. HB0045 is a 1:1 mixture of two humanized monoclonal IgG1 antibodies (mAbs), HB0038 and HB0039. The cocktail not only harnesses the advantages of its parental mAbs in enzyme inhibition but also shows a significantly greater capability of promoting T cell proliferation in vitro. Structural analyses show that HB0045 effectively locks the CD73 dimer in a "partially open" non-active conformation through a double lock mechanism. In various animal models of syngeneic and xenograft tumors, HB0045 inhibits tumor growth more potently than the single mAbs. Collectively, our findings provide functional and structural insights into the mechanism of a CD73-targeting antibody cocktail.
External linksNat Commun / PubMed:39738003 / PubMed Central
MethodsEM (single particle)
Resolution3.06 Å
Structure data

60281

8znz

EMDB-60281, PDB-8znz:
CD73 bound with HB0045
Method: EM (single particle) / Resolution: 3.06 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CD73 / complex / antibody coaktail

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