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TitleStructural basis for full-length chemerin recognition and signaling through chemerin receptor 1.
Journal, issue, pagesCommun Biol, Vol. 7, Issue 1, Page 1598, Year 2024
Publish dateNov 30, 2024
AuthorsAijun Liu / Yezhou Liu / Junlin Wang / Richard D Ye /
PubMed AbstractChemerin, a chemotactic adipokine, plays essential roles in adipogenesis and inflammation. Serum chemerin concentration is closely associated with obesity and metabolism disorders. The mature form of ...Chemerin, a chemotactic adipokine, plays essential roles in adipogenesis and inflammation. Serum chemerin concentration is closely associated with obesity and metabolism disorders. The mature form of chemerin (residues 21-157) acts primarily through chemerin receptor 1 (CMKLR1) for transmembrane signaling. As a result, CMKLR1 serves as a promising target for therapeutic intervention of immunometabolic diseases such as diabetes and multiple sclerosis. Here, we present a high-resolution cryo-EM structure of CMKLR1-Gi signaling complex bound to biologically active full-length chemerin. The mature chemerin shows binding features distinct from its C-terminal nonapeptide including interaction with both the extracellular loops (ECLs) and the N-terminus of CMKLR1. Combining results from functional assays, our studies demonstrate that chemerin interacts with CMKLR1 in a "two-site" mode similar to chemokine-chemokine receptor interactions, but acting as a "reverse chemokine" by inserting its C-terminus instead of the N-terminus as in the case of chemokines into the transmembrane binding pocket of CMKLR1. These structural insights are expected to help develop synthetic analogs with therapeutic potential.
External linksCommun Biol / PubMed:39616240 / PubMed Central
MethodsEM (single particle)
Resolution3.18 Å
Structure data

60144

8zjg

EMDB-60144, PDB-8zjg:
Cryo-EM structure of human CMKLR1-Gi complex bound to chemerin
Method: EM (single particle) / Resolution: 3.18 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • vicugna pacos (alpaca)
KeywordsMEMBRANE PROTEIN / Chemerin Receptor

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