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Structure paper

TitleZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers
Journal, issue, pagesTo Be Published
Publish dateJul 26, 2026 (structure data deposition date)
AuthorsNaydenova K / Mund T / Yip MCJ / Harper CM / Leigh KE / Hankinson J / Boyle KB / Heatley A / Otten EG / Lulla V ...Naydenova K / Mund T / Yip MCJ / Harper CM / Leigh KE / Hankinson J / Boyle KB / Heatley A / Otten EG / Lulla V / Modis Y / Randow F
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.1 - 9.4 Å
Structure data

EMDB-59180, PDB-32ul:
Structure of ZNFX1 in the ATP-bound, pre-ATP hydrolysis state
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-59181, PDB-32um:
Structure of ZNFX1 bound to RNA
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-59182, PDB-32un:
Structure of ZNFX1 in the post-ATP hydrolysis state
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-59183: Helical polymer of human ZNFX1 proteins
Method: EM (single particle) / Resolution: 9.4 Å

EMDB-59184: Structure of the human ZNFX1 protein in a bundled sheet of twisted fibrils
Method: EM (single particle) / Resolution: 4.2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsANTIVIRAL PROTEIN / ZNFX1 / RNA helicase / auto-inhibited / ubiquitin ligase / Zn fingers / armadillo repeat / dimer / ATPase / ATP / pre-ATP hydrolysis / RNA / single-stranded RNA / ADP / Pi / post-ATP hydrolysis

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