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TitleRibosome-Associated Vesicles promote activity-dependent local translation.
Journal, issue, pagesbioRxiv, Year 2024
Publish dateJun 10, 2024
AuthorsEva Martin-Solana / Stephen D Carter / Eric K F Donahue / Jiying Ning / Jill R Glausier / Matias A Preisegger / Leanna Eisenman / Paul N Joseph / Cedric Bouchet-Marquis / Ken Wu / Catherina L Mobini / Amber N Frantz / Stephanie Puig / Cheri M Hampton / Nadine Kabbani / Grant J Jensen / Simon C Watkins / Karl Deisseroth / Lief E Fenno / Michael S Gold / Zachary P Wills / Kristopher Burkewitz / Sulagna Das / Zachary Freyberg /
PubMed AbstractLocal protein synthesis in axons and dendrites underpins synaptic plasticity. However, the composition of the protein synthesis machinery in distal neuronal processes and the mechanisms for its ...Local protein synthesis in axons and dendrites underpins synaptic plasticity. However, the composition of the protein synthesis machinery in distal neuronal processes and the mechanisms for its activity-driven deployment to local translation sites remain unclear. Here, we employed cryo-electron tomography, volume electron microscopy, and live-cell imaging to identify Ribosome-Associated Vesicles (RAVs) as a dynamic platform for moving ribosomes to distal processes. Stimulation via chemically-induced long-term potentiation causes RAV accumulation in distal sites to drive local translation. We also demonstrate activity-driven changes in RAV generation and dynamics , identifying tubular ER shaping proteins in RAV biogenesis. Together, our work identifies a mechanism for ribosomal delivery to distal sites in neurons to promote activity-dependent local translation.
External linksbioRxiv / PubMed:38895376 / PubMed Central
MethodsEM (subtomogram averaging)
Resolution22.0 Å
Structure data

EMDB-58124: In situ subtomogram average of a ribosome bound to ribosome associated vesicle in primary neurons expressing KDEL tagged with mNeonGreen (mNeon-KDEL)
Method: EM (subtomogram averaging) / Resolution: 22.0 Å

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  • Rattus (rats)

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