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TitleCryo-EM structure of human TMEM45A with a bound 2-Hydroxypalmitate.
Journal, issue, pagesJ Struct Biol, Vol. 218, Issue 4, Page 108378, Year 2026
Publish dateSep 26, 2026
AuthorsMariana Grieben / Julica Inderhees / Niklas Ebersberger /
PubMed AbstractThe orphan transmembrane protein 45 A (TMEM45A) is highly expressed in keratinocytes as well as cancer cells under hypoxic conditions, where it contributes to metastasis and chemoresistance. The ...The orphan transmembrane protein 45 A (TMEM45A) is highly expressed in keratinocytes as well as cancer cells under hypoxic conditions, where it contributes to metastasis and chemoresistance. The structure of human TMEM45A, determined with single-particle cryo-electron microscopy (cryo-EM) to 3.27 Å, reveals a homotetrameric assembly of seven-transmembrane-helix protomers. The first six transmembrane helices (TMHs) of each protomer assemble to form a central hydrophobic tunnel containing a 2-hydroxypalmitate.
External linksJ Struct Biol / PubMed:42800517
MethodsEM (single particle)
Resolution3.27 Å
Structure data

56534

28hy

EMDB-56534, PDB-28hy:
Cryo-EM structure of human TMEM45A with a bound 2-Hydroxypalmitate
Method: EM (single particle) / Resolution: 3.27 Å

Chemicals

ChemComp-UNX:
Unknown entry

PDB-1jxz:
Structure of the H90Q mutant of 4-Chlorobenzoyl-Coenzyme A Dehalogenase complexed with 4-hydroxybenzoyl-Coenzyme A (product)

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / orphan transmembrane protein

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