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Structure paper

TitleThe structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology
Journal, issue, pagesSci Adv, Vol. 12, Year 2026
Publish dateNov 11, 2025 (structure data deposition date)
AuthorsHadas Yardeni E / Kiss DJ / Sanchez J / Shavit K / Szepesi Kovacs D / Egyed A / Vogt CD / Gaitonde SA / Glenn J / Canals M ...Hadas Yardeni E / Kiss DJ / Sanchez J / Shavit K / Szepesi Kovacs D / Egyed A / Vogt CD / Gaitonde SA / Glenn J / Canals M / Bouvier M / Newman AH / Lane JR / Keseru GM / Shalev-Benami M
External linksSci Adv / Search PubMed
MethodsEM (single particle)
Resolution2.74 - 3.6 Å
Structure data

55651

9t7q

EMDB-55651, PDB-9t7q:
Cryo-EM structure of EA-Ri-112-bound D3 dopamine receptor with mini-Go
Method: EM (single particle) / Resolution: 3.03 Å

55683

9t88

EMDB-55683, PDB-9t88:
Cryo-EM structure of ESG-2-37-bound D3 dopamine receptor with mini-Go
Method: EM (single particle) / Resolution: 2.74 Å

55685

9t8d

EMDB-55685, PDB-9t8d:
Cryo-EM structure of EA-RK-110-bound D3 dopamine receptor
Method: EM (single particle) / Resolution: 3.6 Å

Chemicals

PDB-1jub:
The K136E mutant of lactococcus lactis dihydroorotate dehydrogenase A

PDB-1juh:
Crystal Structure of Quercetin 2,3-dioxygenase

PDB-1juj:
Human Thymidylate Synthase Bound to dUMP and LY231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
  • synthetic construct (others)
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / GPCR / agonist / inverse-agonist

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