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Structure paper

TitleSerum-stable RNA origami nano-devices
Journal, issue, pagesTo Be Published
Publish dateNov 10, 2025 (structure data deposition date)
AuthorsKristoffersen EL / Zwergius NH / Vallina NS / Gluck N / Stange A / Desdorf L / Civit L / Geary C / Kjems J / Valero J / Andersen ES
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.78 - 6.92 Å
Structure data

EMDB-55621: 2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: PXT origami 'pointer')
Method: EM (single particle) / Resolution: 6.92 Å

EMDB-55622: 2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: Spike core)
Method: EM (single particle) / Resolution: 2.78 Å

EMDB-55623: 2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (Full map, no symmetry)
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-55624: 2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: Spike N-terminal domain (NTD))
Method: EM (single particle) / Resolution: 3.02 Å

55625

9t74

EMDB-55625, PDB-9t74:
2'-fluoro-modified pyrimidine (FY) RNA aptamer binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. (focus map: RBD-aptamer)
Method: EM (single particle) / Resolution: 3.46 Å

Chemicals

ChemComp-MG:
Unknown entry

Source
  • synthetic construct (others)
  • severe acute respiratory syndrome coronavirus 2
  • synthetic rna (others)
KeywordsRNA / origami / modified nucleic acids / XNA / aptamer / 2'fluoro

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