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TitleMechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex
Journal, issue, pagesNat. Commun., Year 2026
Publish dateSep 16, 2025 (structure data deposition date)
AuthorsFoglizzo M / Datta A / Degtjarik O / Perera H / Liburd J / Sykora UM / Ganji RS / Wildsmith G / Chandler F / Campbell LJ ...Foglizzo M / Datta A / Degtjarik O / Perera H / Liburd J / Sykora UM / Ganji RS / Wildsmith G / Chandler F / Campbell LJ / Calabrese AN / Greenberg RA / Zeqiraj E
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.17 - 4.02 Å
Structure data

EMDB-55069: Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Left Arm map)
Method: EM (single particle) / Resolution: 4.02 Å

EMDB-55074: Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Ub (P2) and Ub (P3) map)
Method: EM (single particle) / Resolution: 3.17 Å

EMDB-55086: Cryo-EM structure of the ARISCdC(E33A):K63-Ub4 complex (Left Arm map)
Method: EM (single particle) / Resolution: 3.76 Å

Source
  • Homo sapiens (human)

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