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Structure paper

TitleTo be confirmed, Doxycycline Bound 50S E. coli Ribosome with Rearranged Peptidyl Transferase Centre
Journal, issue, pagesTo Be Published
Publish dateSep 3, 2025 (structure data deposition date)
AuthorsStuart WS / Isupov MN / McLaren M / Jenkins CH / Monier A / Daum B / Norville IH / Gold VAM / Harmer NJ
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.16 Å
Structure data

55001

9slg

EMDB-55001, PDB-9slg:
Doxycycline Bound E. coli Ribosome with Rearranged Peptidyl Transferase Centre
Method: EM (single particle) / Resolution: 2.16 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-DXT:
(4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE / antibiotic*YM

ChemComp-HOH:
WATER

Source
  • Escherichia coli BL21 (bacteria)
  • escherichia coli bl21(de3) (bacteria)
KeywordsRIBOSOME / E. coli / peptidyl transferase centre / inactive ribosome / doxycycline / 50S subunit / rearranged / pathogen / catalytic centre / cryo-EM / antibiotic

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