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Structure paper

TitleStructures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle
Journal, issue, pagesTo Be Published, Year 2026
Publish dateAug 28, 2025 (structure data deposition date)
AuthorsBalch S / Franco-Echevarria E / Kretsch RC / Ghanim GE / Das R / Nguyen THD
External linksTo Be Published / Search PubMed
MethodsEM (single particle)
Resolution3.2 - 3.8 Å
Structure data

54920

9shy

EMDB-54920, PDB-9shy:
Cryo-EM structure of the catalytic core of human telomerase at the initiation state of the repeat addition cycle
Method: EM (single particle) / Resolution: 3.53 Å

54921

9shz

EMDB-54921, PDB-9shz:
Cryo-EM structure of the catalytic core of human telomerase at the elongation state of the repeat addition cycle
Method: EM (single particle) / Resolution: 3.2 Å

54922

9si0

EMDB-54922, PDB-9si0:
Cryo-EM structure of the catalytic core of human telomerase at the pre-termination state of the repeat addition cycle
Method: EM (single particle) / Resolution: 3.8 Å

Chemicals

ChemComp-1GC:
2'-deoxy-5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]guanosine

PDB-1acd:
V32D/F57H MUTANT OF MURINE ADIPOCYTE LIPID BINDING PROTEIN

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / telomerase / H/ACA

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