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Structure paper

TitlePolymerase trapping as mechanism of H5 highly pathogenic avian influenza virus genesis
Journal, issue, pagesScience, Year 2026
Publish dateMay 20, 2025 (structure data deposition date)
AuthorsFunk M / Spronken MI / Hutchinson R / Arragain B / Juyoux P / Bestebroer TM / de Bruin AC / Gultyaev AP / Fouchier RAM / Cusack S ...Funk M / Spronken MI / Hutchinson R / Arragain B / Juyoux P / Bestebroer TM / de Bruin AC / Gultyaev AP / Fouchier RAM / Cusack S / te Vulthuis AJW / Richard M
External linksScience / Search PubMed
MethodsEM (single particle)
Resolution1.99 - 2.15 Å
Structure data

53876

9raf

EMDB-53876, PDB-9raf:
Influenza A/H7N9 polymerase in complex with a 70-mer template in stalled elongation with backtracking and stem.
Method: EM (single particle) / Resolution: 2.15 Å

53877

9rag

EMDB-53877, PDB-9rag:
Influenza A/H7N9 polymerase in complex with a 70-mer RNA template, in stalled elongation.
Method: EM (single particle) / Resolution: 1.99 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-POP:
PYROPHOSPHATE 2-

Source
  • influenza a virus (a/zhejiang/dtid-zju01/2013(h7n9))
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / Influenza polymerase

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