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Structure paper

TitleVariations in Plasmodium tubulin determine unique microtubule architectures, mechanics and drug susceptibility.
Journal, issue, pagesTo Be Published
Publish dateMay 8, 2025 (structure data deposition date)
AuthorsBangera M / Wu J / Fachet D / Ferreira JL / Voth G / Reber S / Moores CA
External linksSearch PubMed
MethodsEM (helical sym.)
Resolution2.9 - 3.2 Å
Structure data

53571

9r4x

EMDB-53571, PDB-9r4x:
13 protofilament P. falciparum paclitaxel stabilised GDP microtubule
Method: EM (helical sym.) / Resolution: 3.2 Å

53572

9r4y

EMDB-53572, PDB-9r4y:
15 protofilament P. falciparum GMPCPP microtubule
Method: EM (helical sym.) / Resolution: 2.9 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-TA1:
TAXOL / medication, chemotherapy*YM

ChemComp-G2P:
PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER / GMP-CPP, energy-carrying molecule analogue*YM

Source
  • plasmodium falciparum 3d7 (eukaryote)
KeywordsSTRUCTURAL PROTEIN / Malaria / parasite / cytoskeleton / microtubule / paclitaxel / GMPCPP

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