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TitleFilament formation and NAD processing by noncanonical human FAM118 sirtuins.
Journal, issue, pagesNat Struct Mol Biol, Vol. 32, Issue 12, Page 2526-2541, Year 2025
Publish dateNov 17, 2025
AuthorsDomagoj Baretić / Sophia Missoury / Karishma Patel / Maximilien Martinez / Franck Coste / Kang Zhu / Rebecca Smith / Anna Georgina Kopasz / Yang Lu / Nicolas Bigot / Catherine Chapuis / Romane Riou / Nina Đukić / Stéphane Goffinont / Valentin Pressoir / Sara Patačko / Gyula Timinszky / Marc Delarue / Bertrand Castaing / Dragana Ahel / Andreja Mikoč / Sébastien Huet / Ivan Ahel / Marcin J Suskiewicz /
PubMed AbstractSirtuins are an ancient family of enzymes with diverse nicotinamide adenine dinucleotide (NAD)-dependent activities. Here we identify family with sequence similarity 118 member B (FAM118B) and ...Sirtuins are an ancient family of enzymes with diverse nicotinamide adenine dinucleotide (NAD)-dependent activities. Here we identify family with sequence similarity 118 member B (FAM118B) and FAM118A-two understudied vertebrate proteins-as vertebrate-specific sirtuins with similarities to bacterial antiphage sirtuins. We show that human FAM118B forms head-to-tail filaments both in vitro and in living human cells, a feature that appears to be conserved in both FAM118B and its paralog FAM118A across vertebrates. While human FAM118B and FAM118A have individually very weak NAD-processing activity in vitro, their interaction leads to markedly increased activity, suggesting a tightly regulated system. The overexpression of wild-type human FAM118B and FAM118A leads to strongly decreased NAD levels in human cells, an effect that is abolished in catalytically dead or filament-deficient mutants. Our study highlights filament formation and NAD processing as conserved mechanisms among immunity-associated sirtuins across evolution.
External linksNat Struct Mol Biol / PubMed:41249820 / PubMed Central
MethodsEM (single particle)
Resolution4.1 - 5.0 Å
Structure data

53487

9r0p

EMDB-53487, PDB-9r0p:
human FAM118B trimeric filament
Method: EM (single particle) / Resolution: 4.1 Å

53488

9r0s

EMDB-53488, PDB-9r0s:
human FAM118B pentameric filament
Method: EM (single particle) / Resolution: 5.0 Å

53555

9r3e

EMDB-53555, PDB-9r3e:
Human FAM118B(34-334) 2 protomers
Method: EM (single particle) / Resolution: 4.8 Å

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / filament / enzyme / NAD / nucleus / innate immunity / sirtuin / HYDROLASE / NADase

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