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Structure paper

TitleInteractions between CNBD and HCND domains control gating inhibition in HCN1 family.
Journal, issue, pagesTo Be Published
Publish dateApr 28, 2025 (structure data deposition date)
AuthorsZorzini V / Gallardo R / Brams M / Ulens C
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.34 - 3.92 Å
Structure data

53514

9r1t

EMDB-53514, PDB-9r1t:
Structure of the human chimera HCN112 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP.
Method: EM (single particle) / Resolution: 3.34 Å

53515

9r1u

EMDB-53515, PDB-9r1u:
Structure of the human HCN1dC hyperpolarization-activated cyclic nucleotide-gated ion channel.
Method: EM (single particle) / Resolution: 3.92 Å

53516

9r1v

EMDB-53516, PDB-9r1v:
Structure of the human chimera HCN112 hyperpolarization-activated cyclic nucleotide-gated ion channel.
Method: EM (single particle) / Resolution: 3.53 Å

Chemicals

ChemComp-CMP:
ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Ion channel / HCN channel / pacemaker channel

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