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Structure paper

TitleDesign principles of a membrane-spanning ubiquitin ligase
Journal, issue, pagesMol Cell, Year 2026
Publish dateApr 2, 2025 (structure data deposition date)
AuthorsWilliams C / Nocka LM / Hedger G / Carrique L / Pusapati GV / Parashara P / Latorraca N / Sarkar P / Lartey D / Gao L ...Williams C / Nocka LM / Hedger G / Carrique L / Pusapati GV / Parashara P / Latorraca N / Sarkar P / Lartey D / Gao L / Pardon E / Milenkovic L / Steyaert J / Chalk R / Bazan F / Rouse SL / Marqusee S / Kong JH / Siebold C / Rohatgi R
External linksMol Cell / Search PubMed
MethodsEM (single particle)
Resolution2.65 - 4.66 Å
Structure data

53313

9qqs

EMDB-53313, PDB-9qqs:
Structure of the MEGF8-MOSMO complex with nanobody 270 (Focused refinement)
Method: EM (single particle) / Resolution: 2.65 Å

53323

9qru

EMDB-53323, PDB-9qru:
Cryo-EM structure of the MMM ubiquitin ligase complex with nanobody 270 (Composite map)
Method: EM (single particle) / Resolution: 3.03 Å

EMDB-53327: Structure of the helix-stabilized MMM ubiquitin ligase complex with nanobody 270 (Consensus map)
Method: EM (single particle) / Resolution: 3.14 Å

EMDB-53328: Focused refinement of the MGRN1 ubiquitin ligase in complex with helix-stabilized MEGF8, MOSMO and nanobody 270
Method: EM (single particle) / Resolution: 4.41 Å

53329

9qs6

EMDB-53329, PDB-9qs6:
Cryo-EM structure of the helix-stabilized MMM ubiquitin ligase complex with nanobody 270 (Composite map)
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-53336: Focused refinement of the MEGF8-MOSMO complex with nanobody 992
Method: EM (single particle) / Resolution: 3.39 Å

EMDB-53337: Focused refinement of the MEGF8 and MOSMO extracellular domains with nanobody 992
Method: EM (single particle) / Resolution: 3.29 Å

EMDB-53338: Focused refinement of the MGRN1 ubiquitin ligase in complex with MEGF8, MOSMO and nanobody 992
Method: EM (single particle) / Resolution: 4.66 Å

EMDB-53339: Structure of the MMM ubiquitin ligase complex with nanobody 992 (Consensus map)
Method: EM (single particle) / Resolution: 3.58 Å

53340

9qsh

EMDB-53340, PDB-9qsh:
Cryo-EM structure of the MMM ubiquitin ligase complex with nanobody 992 (Composite map)
Method: EM (single particle) / Resolution: 3.5 Å

53367

9qty

EMDB-53367, PDB-9qty:
Cryo-EM structure of the binary MEGF8-MOSMO complex with nanobody 270
Method: EM (single particle) / Resolution: 2.98 Å

EMDB-57249: Focused refinement of the helix-stabilized MEGF8-MOSMO complex with nanobody 270
Method: EM (single particle) / Resolution: 2.95 Å

Chemicals

ChemComp-PLM:
PALMITIC ACID

PDB-1jax:
Structure of Coenzyme F420H2:NADP+ Oxidoreductase (FNO)

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / E3 Ubiquitin Ligase / Hedgehog Signaling / Single-pass Membrane Protein / Membrane Protein Complex / Smoothened / Tetraspanin / Cell Surface Receptor / Primary Cilium / Morphogen / Signal Transduction / Human / Carpenter Syndrome / Cancer / Nanobody / Palmitoylation / GDN

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