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Structure paper

TitleCryo-EM structure of bixafen-bound S. cerevisiae complex II unravels SDHI specificity against pathogenic fungi
Journal, issue, pagesCommun Biol, Year 2026
Publish dateMar 6, 2025 (structure data deposition date)
AuthorsPinotsis N / Burn-Leefe C / Jones S / Chen S / Lukoyanova N / Meunier B / Berry EA / Marechal A
External linksCommun Biol / Search PubMed
MethodsEM (single particle)
Resolution3.0 Å
Structure data

53030

9qdm

EMDB-53030, PDB-9qdm:
CRYO-EM STRUCTURE OF THE YEAST RESPIRATORY COMPLEX II WITH THE INHIBITOR BIXAFEN
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-K:
Unknown entry

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-F3S:
FE3-S4 CLUSTER

PDB-1i6x:
STRUCTURE OF A STAR MUTANT CRP-CAMP AT 2.2 A

ChemComp-3PE:
1,2-Distearoyl-sn-glycerophosphoethanolamine / phospholipid*YM

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • saccharomyces cerevisiae w303 (yeast)
KeywordsOXIDOREDUCTASE / COMPLEX II / MEMBRANE PROTEIN / OXIDOREDUCTASE INHIBITOR COMPLEX / BIXAFEN

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