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TitleCryoEM Structure of EAAT1 thermostabilized mutant in Complex with L-Asp, Metal Ions, and the allosteric inhibitor UCPH101 in Salipro and DDS/CHS
Journal, issue, pagesTo Be Published
Publish dateFeb 2, 2025 (structure data deposition date)
AuthorsHorn G / Fu L / Madej MG / Ziegler C
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.84 Å
Structure data

52663

9i7v

EMDB-52663, PDB-9i7v:
EAAT1 thermostabilized mutant in Complex with Rubidium, and the allosteric inhibitor UCPH101 in DDS/CHS
Method: EM (single particle) / Resolution: 3.84 Å

Chemicals

ChemComp-PX6:
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE

ChemComp-6Z6:
2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile

ChemComp-RB:
RUBIDIUM ION

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / TRANSPORT PROTEIN / Glutamate transport / Salipro / L-aspartate

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