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TitleCurbing Autoimmunity: A Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation
Journal, issue, pagesEur. J. Immunol., Year 2026
Publish dateJan 28, 2025 (structure data deposition date)
AuthorsPedersen K / Laursen NS / Green K / Hansen AG / Palarasah Y / Rovsing AB / Kristoffersen EL / Schinkel T / Andersen ES / Valero J ...Pedersen K / Laursen NS / Green K / Hansen AG / Palarasah Y / Rovsing AB / Kristoffersen EL / Schinkel T / Andersen ES / Valero J / Civit L / Troldborg A / Degn SE / Thiel S
External linksEur. J. Immunol. / Search PubMed
MethodsEM (single particle)
Resolution3.4 Å
Structure data

52634

9i5n

EMDB-52634, PDB-9i5n:
Single particle cryo electron microscopy of a Fab fragment bound to recombinant human CD40 ligand
Method: EM (single particle) / Resolution: 3.4 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CD40 ligand inhibitor / CD154 inhibitor / autoimmunity / Fab fragment

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