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Structure paper

TitleEnabling High Throughput Electron Cryo-microscopy for Structure-based Design
Journal, issue, pagesTo Be Published
Publish dateNov 28, 2024 (structure data deposition date)
AuthorsReeks J / Mahajan P / Clark M / Cowan SR / Di Daniel E / Earl CP / Fisher S / Holvey RS / Jackson SM / Lloyd-Evans E ...Reeks J / Mahajan P / Clark M / Cowan SR / Di Daniel E / Earl CP / Fisher S / Holvey RS / Jackson SM / Lloyd-Evans E / Morgillo CM / Mortenson PN / O'Reilly M / Richardson CJ / Schopf P / Tams DM / Waller-Evans H / Ward SE / Whibley S / Williams PA / Johnson CN
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.1 - 2.4 Å
Structure data

52210

9hj6

EMDB-52210, PDB-9hj6:
TRPML1 in complex with compound 2
Method: EM (single particle) / Resolution: 2.3 Å

52211

9hj8

EMDB-52211, PDB-9hj8:
TRPML1 in complex with compound 5
Method: EM (single particle) / Resolution: 2.1 Å

52242

9hl3

EMDB-52242, PDB-9hl3:
TRPML1 in complex with compound 1a
Method: EM (single particle) / Resolution: 2.1 Å

52243

9hl4

EMDB-52243, PDB-9hl4:
TRPML1 in complex with compound 3
Method: EM (single particle) / Resolution: 2.1 Å

52245

9hl6

EMDB-52245, PDB-9hl6:
TRPML1 in complex with compound 4a
Method: EM (single particle) / Resolution: 2.2 Å

52246

9hl8

EMDB-52246, PDB-9hl8:
TRPML1 in complex with compound 8
Method: EM (single particle) / Resolution: 2.2 Å

52248

9hla

EMDB-52248, PDB-9hla:
TRPML1 in complex with compound 9a
Method: EM (single particle) / Resolution: 2.4 Å

52249

9hlb

EMDB-52249, PDB-9hlb:
TRPML1 in complex with compound 10
Method: EM (single particle) / Resolution: 2.1 Å

52250

9hlc

EMDB-52250, PDB-9hlc:
TRPML1 in complex with compound 11
Method: EM (single particle) / Resolution: 2.1 Å

52251

9hld

EMDB-52251, PDB-9hld:
TRPML1 in complex with compound 13
Method: EM (single particle) / Resolution: 2.2 Å

Chemicals

ChemComp-EUJ:
(2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate

PDB-1ivc:
STRUCTURES OF AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE

ChemComp-HEX:
HEXANE

ChemComp-R16:
HEXADECANE

ChemComp-OCT:
N-OCTANE

ChemComp-HOH:
WATER

PDB-1ivd:
STRUCTURES OF AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE

ChemComp-PC1:
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE / phospholipid*YM

ChemComp-D10:
DECANE

ChemComp-D12:
DODECANE

PDB-1ivz:
Solution structure of the SEA domain from murine hypothetical protein homologous to human mucin 16

PDB-1iv0:
Solution structure of the YqgF-family protein (N-terminal fragment)

ChemComp-LNK:
PENTANE

PDB-1iv1:
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase

PDB-1iv2:
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form CDP)

ChemComp-PLC:
DIUNDECYL PHOSPHATIDYL CHOLINE / phospholipid*YM

PDB-1iv3:
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form MG atoms)

ChemComp-8K6:
Octadecane

PDB-1iv4:
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form Substrate)

PDB-1iv5:
New Crystal Form of Human CD81 Large Extracellular Loop.

PDB-1iv6:
Solution Structure of the DNA Complex of Human TRF1

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Ion channel

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