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Structure paper

TitleStructural insights into binding of novel PET tracer MODAG-005 to lipidic alpha-synuclein fibrils
Journal, issue, pagesTo Be Published
Publish dateNov 8, 2024 (structure data deposition date)
AuthorsKim M / Matthes D / Frieg B / Leonov A / Ryazanov S / Bleher D / Grotegerd A-K / Dienemann C / Giese A / Schroeder GF ...Kim M / Matthes D / Frieg B / Leonov A / Ryazanov S / Bleher D / Grotegerd A-K / Dienemann C / Giese A / Schroeder GF / Becker S / Herfert K / de Groot BL / Andreas LB / Griesinger C
External linksSearch PubMed
MethodsEM (helical sym.)
Resolution2.7 - 2.95 Å
Structure data

52038

9hc6

EMDB-52038, PDB-9hc6:
The L2A-I alpha-synuclein fibril in the presence of MODAG-005 (short incubation)
Method: EM (helical sym.) / Resolution: 2.79 Å

52039

9hc7

EMDB-52039, PDB-9hc7:
The L2A-II alpha-synuclein fibril in the presence of MODAG-005 (short incubation)
Method: EM (helical sym.) / Resolution: 2.85 Å

52040

9hc8

EMDB-52040, PDB-9hc8:
The L2C alpha-synuclein fibril in the presence of MODAG-005 (short incubation)
Method: EM (helical sym.) / Resolution: 2.82 Å

52041

9hc9

EMDB-52041, PDB-9hc9:
The L2A-I alpha-synuclein fibril in the presence of MODAG-005 (long incubation)
Method: EM (helical sym.) / Resolution: 2.76 Å

52042

9hca

EMDB-52042, PDB-9hca:
The L2A-II alpha-synuclein fibril in the presence of MODAG-005 (long incubation)
Method: EM (helical sym.) / Resolution: 2.7 Å

52043

9hcb

EMDB-52043, PDB-9hcb:
The L2C alpha-synuclein fibril in the presence of MODAG-005 (long incubation)
Method: EM (helical sym.) / Resolution: 2.95 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / alpha-synuclein / fibril / MODAG-005 / PET tracer

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