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Structure paper

TitleSmall molecules restore mutant mitochondrial DNA polymerase activity
Journal, issue, pagesTo Be Published, Year 2025
Publish dateAug 13, 2024 (structure data deposition date)
AuthorsValenzuela S / Xuefeng Z / Macao M / Stamgren M / Geukens C / Charifson PS / Kern G / Hoberg E / Jenninger L / Gruszczyk AV ...Valenzuela S / Xuefeng Z / Macao M / Stamgren M / Geukens C / Charifson PS / Kern G / Hoberg E / Jenninger L / Gruszczyk AV / Lee S / Johansson KAS / Miralles Fuste J / Shi Y / Kerns SJ / Arabanian L / Martinez Botella G / Green J / Griffin A / Pardo Hernandez C / Keating TA / Larsson NG / Phan C / Posse V / Jones JE / Xie X / Giroux S / Gustafsson CM / Falkenberg M
External linksTo Be Published / Search PubMed
MethodsEM (single particle)
Resolution2.39 - 2.69 Å
Structure data

51326

9ggb

EMDB-51326, PDB-9ggb:
Structure of the G848S mutant of human mitochondrial DNA polymerase gamma in complex with PZL-A
Method: EM (single particle) / Resolution: 2.63 Å

51327

9ggc

EMDB-51327, PDB-9ggc:
Structure of the G848S mutant of human mitochondrial DNA polymerase gamma
Method: EM (single particle) / Resolution: 2.39 Å

51328

9ggd

EMDB-51328, PDB-9ggd:
Structure of the A467T mutant of human mitochondrial DNA polymerase gamma in complex with PZL-A
Method: EM (single particle) / Resolution: 2.67 Å

51329

9gge

EMDB-51329, PDB-9gge:
Structure of the A467T mutant of human mitochondrial DNA polymerase gamma
Method: EM (single particle) / Resolution: 2.69 Å

51330

9ggf

EMDB-51330, PDB-9ggf:
Structure of WT human mitochondrial DNA polymerase gamma
Method: EM (single particle) / Resolution: 2.65 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

PDB-1ik1:
Solution Structure of an RNA Hairpin from HRV-14

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / Mitochondrial DNA polymerase / activator / TRANSFERASE-DNA complex

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