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-Structure paper
| Title | Structures of Vibrio cholerae transcription complexes reveal how ToxR and TcpP recruit the RNA polymerase and activate virulence genes |
|---|---|
| Journal, issue, pages | Science Advances, Year 2025 |
| Publish date | Aug 6, 2024 (structure data deposition date) |
Authors | Alcaide-Jimenez A / Canals A / Baudin F / Machon C / Fabrega-Ferrer M / Bantysh O / Perez-Luque R / Murciano B / Mohammad AA / Rowse MJ ...Alcaide-Jimenez A / Canals A / Baudin F / Machon C / Fabrega-Ferrer M / Bantysh O / Perez-Luque R / Murciano B / Mohammad AA / Rowse MJ / Ferracciolo JM / Krukonis ES / Muller CW / Coll M |
External links | Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.6 - 7.2 Å |
| Structure data | EMDB-51273, PDB-9gdo: EMDB-51274, PDB-9gdp: EMDB-51275, PDB-9gdq: EMDB-51276, PDB-9gdr: EMDB-51277, PDB-9gds: ![]() EMDB-51278: Cryo-EM structure of Vibrio cholerae RNA polymerase dimer with ToxR and TcpP transcription factors and a toxT promoter DNA fragment ![]() EMDB-51774: Consensus map of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with ToxR transcription factor and bound to an ompU promoter DNA fragment ![]() EMDB-51775: Focused map #1 of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with ToxR transcription factor and bound to an ompU promoter DNA fragment ![]() EMDB-51776: Focused map #2 of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with ToxR transcription factor and bound to an ompU promoter DNA fragment ![]() EMDB-51948: Consensus map of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with TcpP transcription factor and bound to a toxT promoter DNA fragment ![]() EMDB-51949: Focused map #1 of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with TcpP transcription factor and bound to a toxT promoter DNA fragment ![]() EMDB-51950: Focused map #2 of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with TcpP transcription factor and bound to a toxT promoter DNA fragment ![]() EMDB-51955: Consensus map of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with ToxR and TcpP transcription factors and bound to a toxT promoter DNA fragment ![]() EMDB-51956: Focused map #1 of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with ToxR and TcpP transcription factors and bound to a toxT promoter DNA fragment ![]() EMDB-51958: Focused map #2 of the cryo-EM structure of Vibrio cholerae RNA polymerase Transcription Activation Complex with ToxR and TcpP transcription factors and bound to a toxT promoter DNA fragment |
| Chemicals | ![]() ChemComp-MG: ![]() ChemComp-ZN: |
| Source |
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Keywords | TRANSCRIPTION / RNA polymerase / Open promoter complex / ompU / Vibrio cholerae / Transcription Activation Complex / toxT / TcpP / ToxR |
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vibrio cholerae o395 (bacteria)
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