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TitleCryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state
Journal, issue, pagesTo Be Published
Publish dateMay 10, 2024 (structure data deposition date)
AuthorsKasaragod VB / Aricescu AR
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.9 Å
Structure data

50285

9fax

EMDB-50285, PDB-9fax:
CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-R16:
HEXADECANE

ChemComp-PX2:
1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE

ChemComp-CLR:
CHOLESTEROL

ChemComp-PGW:
(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl / phospholipid*YM

ChemComp-HEX:
HEXANE

ChemComp-D10:
DECANE

ChemComp-PLM:
PALMITIC ACID

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / GABA / Neurotransmission / Ternary complex / Inhibitory synapse

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