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| Title | Optimized dibenzothiazepinones activate the impaired ribosome biogenesis checkpoint and trigger p53-dependent apoptosis by inhibiting the 60S assembly factor NVL |
|---|---|
| Journal, issue, pages | To Be Published |
| Publish date | Mar 28, 2025 (structure data deposition date) |
Authors | Guo HH / Tao Y / Cruz VE / Fang M / Khivansara V / Xie S / Leach A / Rivera-Cancel G / Barrows N / Williams N ...Guo HH / Tao Y / Cruz VE / Fang M / Khivansara V / Xie S / Leach A / Rivera-Cancel G / Barrows N / Williams N / Aurora A / Erzberger JP / De Brabander JK / Nijhawan D |
External links | Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.86 Å |
| Structure data | EMDB-49941, PDB-9nyp: |
| Chemicals | ![]() ChemComp-ATP: ![]() ChemComp-MG: ![]() ChemComp-ADP: ![]() PDB-1b7f: ![]() ChemComp-HOH: |
| Source |
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Keywords | TRANSLOCASE / Ribosome biogenesis / AAA+ ATPase |
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homo sapiens (human)
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