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TitleCAR-BOOSTing T-Cell Responsiveness through Synaptic Cleft Engineering
Journal, issue, pagesTo Be Published
Publish dateFeb 4, 2025 (structure data deposition date)
AuthorsMirazee J / Aranganathan A / Chen X / Tiwary P / Ding J / Mizuno N / Walters KJ / Taylor N / Gregoire AB
External linksSearch PubMed
MethodsEM (tomography)
Resolution1.91 - 6.69 Å
Structure data

EMDB-48920: Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H47 CD19 CAR construct
Method: EM (tomography) / Resolution: 6.69 Å

EMDB-48925: Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H15 CD19 CAR construct
Method: EM (tomography) / Resolution: 6.69 Å

EMDB-48951: Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H15 CD19 CAR construct
Method: EM (tomography) / Resolution: 6.69 Å

EMDB-49041: Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H47 CD19 CAR construct
Method: EM (tomography) / Resolution: 6.69 Å

EMDB-49051: Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H8 CD19 CAR construct, (sample2, region3).
Method: EM (tomography) / Resolution: 1.91 Å

EMDB-49052: Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H8 CD19 CAR construct, (sample2, region2).
Method: EM (tomography) / Resolution: 1.91 Å

EMDB-49054: Cryo-ET of FIB-milled synapse region between CD19+ NALM6 leukemia cells and T-cells expressing 8H8 CD19 CAR construct, (sample 1).
Method: EM (tomography) / Resolution: 4.61 Å

Source
  • Homo sapiens (human)

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