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TitleActivation of the M4 muscarinic acetylcholine receptor by the bitopic agonist C110
Journal, issue, pagesTo Be Published
Publish dateJan 23, 2025 (structure data deposition date)
AuthorsKaoullas MG / Mobbs JI / Venugopal H / Thal DM
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.57 - 2.83 Å
Structure data

EMDB-48778: Focused refinement map of the human M4 muscarinic acetylcholine receptor bound to the bitopic agonist C110
Method: EM (single particle) / Resolution: 2.83 Å

48779

9n09

EMDB-48779, PDB-9n09:
Human M4 muscarinic acetylcholine receptor Gi1 complex (mini-Gsi chimera) bound to the bitopic agonist C110
Method: EM (single particle) / Resolution: 2.57 Å

Chemicals

ChemComp-5XI:
methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsSIGNALING PROTEIN / G protein-coupled receptor / adenosine binding / seven transmembrane protein / MEMBRANE PROTEIN

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