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TitleCo-inhibition of Transcription Reduces Rifampicin Resistance and Enhances Killing of Mycobacterium tuberculosis.
Journal, issue, pagesTo Be Published
Publish dateJan 8, 2025 (structure data deposition date)
AuthorsBarbara B / Lilic M / Campbell EA
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.97 Å
Structure data

48561

9mrq

EMDB-48561, PDB-9mrq:
Mycobacterium tuberculosis RNA polymerase elongation complex bound to inhibitor N-aroyl-N-aryl-phenylalanine amide (AAP)-SO2
Method: EM (single particle) / Resolution: 2.97 Å

Chemicals

PDB-1bnv:
CARBONIC ANHYDRASE II INHIBITOR

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
  • mycobacterium tuberculosis h37rv (bacteria)
KeywordsTRANSCRIPTION / TRANSFERASE/INHIBITOR / RNA polymerase / TRANSFERASE-INHIBITOR complex / Elongation / Transcription Inhibitor

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