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TitleMERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies.
Journal, issue, pagesiScience, Vol. 28, Issue 2, Page 111632, Year 2025
Publish dateFeb 21, 2025
AuthorsOlubukola M Abiona / Nianshuang Wang / Sarah R Leist / Alexandra Schäfer / Adam S Cockrell / Lingshu Wang / Sandhya Bangaru / Laura Stevens / Rachel L Graham / Jacob F Kocher / Yaroslav Tsybovsky / Masaru Kanekiyo / Azad Kumar / Kaitlyn M Morabito / Osnat Rosen / Wei Shi / Anne Werner / Yi Zhang / Cynthia Ziwawo / Christian K O Dzuvor / Charis Palandjian / Connor Eastman / Hannah R Matthews / Jeswin Joseph / James D Chappell / Wing-Pui Kong / John R Mascola / Andrew B Ward / Mark R Denison / Ralph Baric / Jason S McLellan / Barney S Graham / Kizzmekia S Corbett-Helaire /
PubMed AbstractThe COVID-19 pandemic underscores the need to prepare for future emerging coronavriuses (CoVs) by understanding the principles behind effective CoV vaccine design such as protective immunity and ...The COVID-19 pandemic underscores the need to prepare for future emerging coronavriuses (CoVs) by understanding the principles behind effective CoV vaccine design such as protective immunity and antibody responses. To study which epitopes and subdomains contribute to protection, we utilized the prefusion-stabilized spike protein of MERS-CoV, MERS S-2P, as a vaccine immunogen. Vaccination with MERS S-2P elicited both receptor-binding domain (RBD)- and non-RBD-specific antibodies, including N-terminal domain (NTD)-specific G2-and CDC2-A2-like antibodies. Intriguingly, the immunogen MERS S-2P_ΔRBD, MERS S-2P with the RBDs removed, protects comparably to S1 and S-2P immunogens against MERS-CoV challenge. Moreover, passive transfer studies of polyclonal IgG from MERS S-2P immunized mice depleted of subdomain-specific antibodies demonstrated that non-RBD antibodies protected more than non-NTD antibodies. Altogether, these findings illustrate that protection is not solely driven by RBD-specific antibodies and highlights the importance of targeting non-RBD sites in future CoV vaccine designs.
External linksiScience / PubMed:39898019 / PubMed Central
MethodsEM (single particle)
Resolution20.0 Å
Structure data

EMDB-46715: MERS NTD-specific polyclonal antibodies
Method: EM (single particle) / Resolution: 20.0 Å

Source
  • Middle East respiratory syndrome-related coronavirus

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