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TitleARL3 GTPases facilitate ODA16 unloading from IFT in motile cilia.
Journal, issue, pagesSci Adv, Vol. 10, Issue 36, Page eadq2950, Year 2024
Publish dateSep 6, 2024
AuthorsYameng Huang / Xiaoduo Dong / Stella Y Sun / Teck-Kwang Lim / Qingsong Lin / Cynthia Y He /
PubMed AbstractEukaryotic cilia and flagella are essential for cell motility and sensory functions. Their biogenesis and maintenance rely on the intraflagellar transport (IFT). Several cargo adapters have been ...Eukaryotic cilia and flagella are essential for cell motility and sensory functions. Their biogenesis and maintenance rely on the intraflagellar transport (IFT). Several cargo adapters have been identified to aid IFT cargo transport, but how ciliary cargos are discharged from the IFT remains largely unknown. During our explorations of small GTPases ARL13 and ARL3 in , we found that ODA16, a known IFT cargo adapter present exclusively in motile cilia, is a specific effector of ARL3. In the cilia, active ARL3 GTPases bind to ODA16 and dissociate ODA16 from the IFT complex. Depletion of ARL3 GTPases stabilizes ODA16 interaction with the IFT, leading to ODA16 accumulation in cilia and defects in axonemal assembly. The interactions between human ODA16 homolog HsDAW1 and ARL GTPases are conserved, and these interactions are altered in HsDAW1 disease variants. These findings revealed a conserved function of ARL GTPases in IFT transport of motile ciliary components, and a mechanism of cargo unloading from the IFT.
External linksSci Adv / PubMed:39231220 / PubMed Central
MethodsEM (tomography)
Resolution10.7 - 11.02 Å
Structure data

EMDB-45648: Representative cryo electron tomography reconstructions showing central pair microtubule alignment in a wild type Trypanosoma brucei cell
Method: EM (tomography) / Resolution: 11.02 Å

EMDB-45649: Representative cryo electron tomography reconstructions showing central pair microtubule misalignment in TbArl3A and TbArl3C dual RNAi cells.
Method: EM (tomography) / Resolution: 10.7 Å

Source
  • Trypanosoma brucei (eukaryote)

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