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TitleDibenzothiazepinones are bioavailable inhibitors of NVL and cause p53-dependent apoptosis in cancer by blocking 60S ribosome assembly
Journal, issue, pagesTo Be Published
Publish dateApr 25, 2024 (structure data deposition date)
AuthorsGuo HH / Tao Y / Cruz VE / Fang M / Khivansara V / Xie S / Leach A / Rivera-Cancel G / Barrows N / Williams N ...Guo HH / Tao Y / Cruz VE / Fang M / Khivansara V / Xie S / Leach A / Rivera-Cancel G / Barrows N / Williams N / Aurora A / Erzberger JP / De Brabander JK / Nijhawan D
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.83 - 3.06 Å
Structure data

44633

9bji

EMDB-44633, PDB-9bji:
Cryo-EM structure of apo NVL
Method: EM (single particle) / Resolution: 2.83 Å

44634

9bjj

EMDB-44634, PDB-9bjj:
Cryo-EM structure of NVL bound the the MM017 inhibitor
Method: EM (single particle) / Resolution: 3.06 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

PDB-1ap0:
STRUCTURE OF THE CHROMATIN BINDING (CHROMO) DOMAIN FROM MOUSE MODIFIER PROTEIN 1, NMR, 26 STRUCTURES

Source
  • homo sapiens (human)
  • escherichia coli bl21(de3) (bacteria)
KeywordsTRANSLOCASE / Ribosome biogenesis / AAA+ ATPase

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