EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity.
ジャーナル・号・ページ	Nat Commun, Vol. 16, Issue 1, Page 8449, Year 2025
掲載日	2025年9月26日
著者	Summa Bibby / James Jung / Yu Shang Low / Alberto A Amarilla / Natalee D Newton / Connor A P Scott / Jessica Balk / Yi Tian Ting / Morgan E Freney / Benjamin Liang / Timothy Grant / Fasséli Coulibaly / Paul Young / Roy A Hall / Jody Hobson-Peters / Naphak Modhiran / Daniel Watterson /
PubMed 要旨	Yellow fever virus (YFV) is a re-emerging flavivirus that causes severe hepatic disease and mortality in humans. Despite being researched for over a century, the structure of YFV has remained elusive. ...Yellow fever virus (YFV) is a re-emerging flavivirus that causes severe hepatic disease and mortality in humans. Despite being researched for over a century, the structure of YFV has remained elusive. Here we use a chimeric virus platform to resolve the first high resolution cryo-EM structures of YFV. Stark differences in particle morphology and homogeneity are observed between vaccine and virulent strains of YFV, and these are found to have significant implications on antibody recognition and neutralisation. We identify a single residue (R380) in the YFV envelope protein that stabilises the virion surface, and leads to reduced exposure of the cross-reactive fusion loop epitope. The differences in virion morphology between YFV strains also contribute to the reduced sensitivity of the virulent YFV virions to vaccine-induced antibodies. These findings have significant implications for YFV biology, vaccinology and structure-based flavivirus antigen design.
リンク	Nat Commun / PubMed:41006244 / PubMed Central
手法	EM (単粒子) / X線回折
解像度	2.66 - 21.8 Å
構造データ	EMDB-44278: Chimeric flavivirus between BinJV and YFV-17D 手法: EM (単粒子) / 解像度: 7.5 Å EMDB-44279: Chimeric flavivirus between BinJV and YFV-ES504 手法: EM (単粒子) / 解像度: 12.6 Å EMDB-44280: Chimeric flavivirus between BinJV and YFV-17D in complex with 2C9 Fab 手法: EM (単粒子) / 解像度: 7.3 Å EMDB-44281: Chimeric flavivirus between BinJV and YFV-ES504 in complex with 2C9 Fab 手法: EM (単粒子) / 解像度: 21.8 Å EMDB-44282: Chimeric flavivirus between BinJV and YFV-17D in complex with 5A Fab 手法: EM (単粒子) / 解像度: 11.8 Å EMDB-44283: Chimeric flavivirus between BinJV and YFV-ES504 in complex with 5A Fab 手法: EM (単粒子) / 解像度: 15.5 Å EMDB-44284: Chimeric flavivirus between BinJV and YFV-ES504 with YFV-17D DIII 手法: EM (単粒子) / 解像度: 6.5 Å EMDB-44285: Chimeric flavivirus between BinJV and YFV-ES504 with YFV-17D DIII in complex with 2C9 Fab 手法: EM (単粒子) / 解像度: 8.1 Å EMDB-44286: Chimeric flavivirus between BinJV and YFV-Asibi with YFV-17D DIII 手法: EM (単粒子) / 解像度: 5.5 Å EMDB-44287: Chimeric flavivirus between BinJV and YFV-ES504 T380R 手法: EM (単粒子) / 解像度: 5.7 Å 44288 9b6u EMDB-44288, PDB-9b6u: Envelope protein ASU of YFV-17D in complex with 2C9 Fab 手法: EM (単粒子) / 解像度: 4.0 Å 44289 9b6v EMDB-44289, PDB-9b6v: Envelope protein ASU of YFV-ES504 with YFV-17D DIII 手法: EM (単粒子) / 解像度: 3.3 Å 44290 9b6w EMDB-44290, PDB-9b6w: Envelope protein ASU of YFV-ES504 with YFV-17D DIII in complex with 2C9 Fab 手法: EM (単粒子) / 解像度: 3.6 Å 44291 9b6x EMDB-44291, PDB-9b6x: Envelope protein ASU of YFV-Asibi with YFV-17D DIII 手法: EM (単粒子) / 解像度: 3.6 Å 44292 9b6y EMDB-44292, PDB-9b6y: Envelope protein ASU of YFV-ES504 T380R 手法: EM (単粒子) / 解像度: 3.3 Å EMDB-49804: Chimeric flavivirus between BinJV and YFV-Asibi 手法: EM (単粒子) / 解像度: 12.5 Å EMDB-49805: Chimeric flavivirus between BinJV and YFV-Asibi T380R 手法: EM (単粒子) / 解像度: 8.6 Å PDB-9b8g: 2C9 Fab antibody fragment against the E protein of the Yellow Fever virus 手法: X-RAY DIFFRACTION / 解像度: 2.66 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン ChemComp-CL: Unknown entry / クロリド ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-HOH: WATER
由来	mus musculus (ハツカネズミ) yellow fever virus (黄熱ウイルス) homo sapiens (ヒト)
キーワード	VIRUS/IMMUNE SYSTEM / Flavivirus / Envelope protein / Yellow fever virus / Fab / VIRUS / VIRUS-IMMUNE SYSTEM complex / IMMUNE SYSTEM / Antibody / Yellow Fever