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TitleHuman naïve B cells recognize prepandemic influenza virus hemagglutinins.
Journal, issue, pagesSci Immunol, Vol. 10, Issue 103, Page eado9572, Year 2025
Publish dateJan 24, 2025
AuthorsJared Feldman / Ana Sofia Ferreira Ramos / Mya Vu / Daniel P Maurer / Victoria C Rosado / Daniel Lingwood / Goran Bajic / Aaron G Schmidt /
PubMed AbstractUnderstanding the naïve B cell repertoire and its specificity for potential zoonotic threats, such as the highly pathogenic avian influenza (HPAI) H5Nx viruses, may allow prediction of infection- or ...Understanding the naïve B cell repertoire and its specificity for potential zoonotic threats, such as the highly pathogenic avian influenza (HPAI) H5Nx viruses, may allow prediction of infection- or vaccine-specific responses. However, this naïve repertoire and the possibility to respond to emerging, prepandemic viruses are largely undetermined. Here, we profiled naïve B cell reactivity against a prototypical HPAI H5 hemagglutinin (HA), the major target of antibody responses. We found that the frequency of H5-specific human naïve B cells targeting the HA "head" domain was increased relative to cross-reactive B cells to a circulating seasonal H1N1 strain. We classified the isolated monoclonal antibodies (mAbs) by the HA epitopes engaged and found that selected mAbs neutralized H5N1 at germline. We determined a cryo-electron microscopic structure of one mAb in complex with H5 HA to define its epitope. Our study defines the naïve human B cell repertoire recognizing a potentially zoonotic HPAI.
External linksSci Immunol / PubMed:39854479 / PubMed Central
MethodsEM (single particle)
Resolution3.1 Å
Structure data

42377

8ume

EMDB-42377, PDB-8ume:
Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • influenza a virus
KeywordsVIRAL PROTEIN / Hemagglutinin / Influenza A / Antibody / Fab

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