Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.
Journal, issue, pages	Nat Commun, Vol. 15, Issue 1, Page 10012, Year 2024
Publish date	Nov 19, 2024
Authors	Ju Sun / Tianyi Zheng / Mingjun Jia / Yanjun Wang / Jingru Yang / Yun Liu / Pengyun Yang / Yufeng Xie / Honglei Sun / Qi Tong / Jiaming Li / Jing Yang / Guanghua Fu / Yi Shi / Jianxun Qi / Wenjun Liu / Jinhua Liu / Wen-Xia Tian / George F Gao / Yuhai Bi /
PubMed Abstract	The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the ...The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the A(H2N2)pdm1957. One H2N2 AIV has a dual receptor-binding property similar to that of the A(H2N2)pdm1957. Molecular and structural studies reveal that the N144S, and N144E or R137M substitutions in hemagglutinin (HA) enable H2N2 avian or human viruses to bind or preferentially bind human-type receptor. The H2N2 AIV rapidly adapts to mice (female) and acquires mammalian-adapted mutations that facilitated transmission in guinea pigs and ferrets (female). These findings on the receptor-binding, infectivity, transmission, and mammalian-adaptation characteristics of H2N2 AIVs provide a reference for early-warning and prevention for this subtype.
External links	Nat Commun / PubMed:39562538 / PubMed Central
Methods	EM (single particle)
Resolution	2.31 - 2.87 Å
Structure data	38311 8xg1 EMDB-38311, PDB-8xg1: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.53 Å 38348 8xhe EMDB-38348, PDB-8xhe: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.64 Å 38349 8xhf EMDB-38349, PDB-8xhf: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.39 Å 38350 8xhg EMDB-38350, PDB-8xhg: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.54 Å 38351 8xhh EMDB-38351, PDB-8xhh: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.38 Å 38597 8xr7 EMDB-38597, PDB-8xr7: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.62 Å 38598 8xr8 EMDB-38598, PDB-8xr8: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.53 Å 38599 8xr9 EMDB-38599, PDB-8xr9: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.6 Å 38600 8xra EMDB-38600, PDB-8xra: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.31 Å 38601 8xrb EMDB-38601, PDB-8xrb: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.49 Å 38602 8xrc EMDB-38602, PDB-8xrc: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.5 Å 38603 8xrd EMDB-38603, PDB-8xrd: Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus Method: EM (single particle) / Resolution: 2.87 Å
Chemicals	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose ChemComp-SIA: N-acetyl-alpha-neuraminic acid
Source	influenza a virus (strain a/korea/426/1968 h2n2) influenza a virus
Keywords	VIRAL PROTEIN / H2N2 / influenza virus / receptor / replication / transmission / mice / guinea pig / ferret / mutation / public health risk / VIRUS