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TitleStructural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor.
Journal, issue, pagesSci Adv, Vol. 10, Issue 33, Page eadn7771, Year 2024
Publish dateAug 16, 2024
AuthorsZhangsong Wu / Geng Chen / Chen Qiu / Xiaoyi Yan / Lezhi Xu / Shirui Jiang / Jun Xu / Runyuan Han / Tingyi Shi / Yiming Liu / Wei Gao / Qian Wang / Jiancheng Li / Fang Ye / Xin Pan / Zhiyi Zhang / Peiruo Ning / Binghao Zhang / Jing Chen / Yang Du /
PubMed AbstractKisspeptin receptor (KISS1R), belonging to the class A peptide-GPCR family, plays a key role in the regulation of reproductive physiology after stimulation by kisspeptin and is regarded as an ...Kisspeptin receptor (KISS1R), belonging to the class A peptide-GPCR family, plays a key role in the regulation of reproductive physiology after stimulation by kisspeptin and is regarded as an attractive drug target for reproductive diseases. Here, we demonstrated that KISS1R can couple to the G pathway besides the well-known G pathway. We further resolved the cryo-electron microscopy (cryo-EM) structure of KISS1R-G and KISS1R-G complexes bound to the synthetic agonist TAK448 and structure of KISS1R-G complex bound to the endogenous agonist KP54. The high-resolution structures provided clear insights into mechanism of KISS1R recognition by its ligand and can facilitate the design of targeted drugs with high affinity to improve treatment effects. Moreover, the structural and functional analyses indicated that conformational differences in the extracellular loops (ECLs), intracellular loops (ICLs) of the receptor, and the "wavy hook" of the Gα subunit may account for the specificity of G protein coupling for KISS1R signaling.
External linksSci Adv / PubMed:39151001 / PubMed Central
MethodsEM (single particle)
Resolution2.68 - 3.0 Å
Structure data

38329

8xgo

EMDB-38329, PDB-8xgo:
a peptide receptor complex structure
Method: EM (single particle) / Resolution: 2.68 Å

38331

8xgs

EMDB-38331, PDB-8xgs:
a peptide receptor complex structure
Method: EM (single particle) / Resolution: 2.95 Å

38332

8xgu

EMDB-38332, PDB-8xgu:
a peptide receptor complex structure
Method: EM (single particle) / Resolution: 3.0 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSTRUCTURAL PROTEIN/IMMUNE SYSTEM / a peptide related GPCR-Gq complex / STRUCTURAL PROTEIN / STRUCTURAL PROTEIN-IMMUNE SYSTEM complex

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