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| Title | Competition propels, rather than limits, the success of low-affinity B cells in the germinal center response. |
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| Journal, issue, pages | Cell Rep, Vol. 44, Issue 2, Page 115334, Year 2025 |
| Publish date | Feb 15, 2025 |
 Authors | Runhan Li / Keyan Bao / Can Liu / Xuejing Ma / Zhaolin Hua / Ping Zhu / Baidong Hou /  |
| PubMed Abstract | The germinal center (GC) sets an environment where antigen-specific B cells are compelled to continuously increase their affinity to compete for the antigen and obtain Tfh help for survival and ...The germinal center (GC) sets an environment where antigen-specific B cells are compelled to continuously increase their affinity to compete for the antigen and obtain Tfh help for survival and propagation. Previous studies indicated that low-affinity B cells are disadvantaged in the presence of high-affinity ones, suggesting that competition may lead to the elimination of low-affinity B cells and their descendants. However, using a multivalent virus-mimicking antigen, our study demonstrates that low-affinity B cells not only successfully participate in GC responses alongside high-affinity B cells but also undergo accelerated affinity maturation under the more stringent competition. Furthermore, our cryo-electron-microscopy-based structural analysis reveals that both low-affinity and high-affinity B cells compete for the same antigenic epitope. Although the applicability of this idealized GC competition to true pathogen-induced responses remains uncertain, this change in perspective on the role of competition in low-affinity B cell evolution provides valuable insights for vaccine development. |
 External links | Cell Rep / PubMed:39955776 |
| Methods | EM (single particle) |
| Resolution | 2.8 - 4.3 Å |
| Structure data | EMDB-37286, PDB-8w5d: EMDB-37287, PDB-8w5e: EMDB-37290, PDB-8w5f: EMDB-37291, PDB-8w5g: EMDB-37292, PDB-8w5h: EMDB-37293, PDB-8w5i: EMDB-37296, PDB-8w5l: EMDB-37297, PDB-8w5m: EMDB-37298, PDB-8w5n: EMDB-37299, PDB-8w5o: EMDB-37300, PDB-8w5p: EMDB-37301, PDB-8w5q: EMDB-37302, PDB-8w5r: EMDB-37303, PDB-8w5t: EMDB-37304, PDB-8w5u: EMDB-37305, PDB-8w5v: EMDB-37306, PDB-8w5w: |
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 Keywords | IMMUNE SYSTEM / Qb / cryo-EM / Antibody |
mus musculus (house mouse)
escherichia phage qbeta (virus)